introduction: celastrus paniculatus seed oil, commonly known as malkangni or jyotishmati, was in use from time immemorial to treat brain related disorders. celastrus paniculatus seed oil has significant antidepressant-like activity in chronic unpredictable stressed mice. the present study was undertaken to evaluate the antidepressant-like effect of celastrus paniculatus seed oil in unstressed m...

asperugo procumbents l. has been used in iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. the present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice.additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...

objective: pimpinella anisum (p. anisum) has different pharmacological properties such as anticonvulsant, analgesic, tranquilizer, antidepressant and anti-anxiety effects. in this study the antidepressant-like effect of aqueous and ethanolic extracts of p. anisum fruit in mice was investigated. materials and methods: forced swimming test (fst) and tail suspension test (tst) were used to determi...

OBJECTIVE To determine the predictive validity of some of the commonly employed models of mania and depression using standard drugs i.e. lithium (70 mg/kg) and lamotrigine (5 mg/kg) in male Wistar rats. METHODS The depression facet of bipolar disorder was evaluated using forced swim test, tail suspension test, and chronic mild stress test. The models used to evaluate the mania facet of bipola...

The tail-suspension test is a mouse behavioral test useful in the screening of potential antidepressant drugs, and assessing of other manipulations that are expected to affect depression related behaviors. Mice are suspended by their tails with tape, in such a position that it cannot escape or hold on to nearby surfaces. During this test, typically six minutes in duration, the resulting escape ...

To study anxiolytic and antidepressant effect of Astaxanthin as an adjuvant to standard drug.In this study, to investigate the effects of astaxanthin on anxiety and depression,we performed some behavioural trials including elevated plus maze test, hole-board test, forced swim test, and tail suspension test.Astaxanthin ( 3 mg/kg/day for 15 days, orally) significantly increased the time spent in ...

Background & Aim: Depression is a heterogeneous mood disorder affecting both people in developing and developed countries. The drugs used in its management are associated with adverse effects and delayed response which compromise their therapeutic benefits. This makes it worthwhile to look for antidepressants plants with proven advantage and favourable benefit-...

introduction: depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. the presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. during the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. am...

Introduction: Depressive disorder is a prevalent psychiatric disorder, which affects 21% of the world population. The presently using drugs can impose a variety of side-effects including cardiac toxicity, hypopiesia, sexual dysfunction, body weight gain, and sleep disorder. During the last decade, there is a growing interest in the therapeutic effects of natural products on mental disorders. Am...